PHAGE RESISTANCE IN MULTIDRUG-RESISTANT KLEBSIELLA PNEUMONIAE ST258 EVOLVES VIA DIVERSE MUTATIONS THAT CULMINATE IN IMPAIRED ADSORPTION

Phage Resistance in Multidrug-Resistant Klebsiella pneumoniae ST258 Evolves via Diverse Mutations That Culminate in Impaired Adsorption

ABSTRACT The evolution of phage resistance poses an inevitable threat to the efficacy of phage therapy.The strategic selection of phage combinations that impose high genetic barriers to resistance and/or high compensatory fitness costs may mitigate this threat.However, for such a strategy to be effective, the evolution of phage resistance must be s

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Elementary Siphon-Based Robust Control for Automated Manufacturing Systems With Multiple Unreliable Resources

Resources in a real-world automated manufacturing system may be unreliable, thus paralyzing many existing deadlock control strategies.This paper defines robust legal markings and proposes a two-step robust deadlock control policy for systems of the simple sequential process with resources based on elementary siphons.The first step, called elementar

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